Dataset Information

Next-Generation Sequencing Reveals the Progression of COVID-19.

ABSTRACT: The novel coronavirus SARS-CoV-2 (causing the disease COVID-19) has caused a highly transmissible and ongoing pandemic worldwide. Due to its rapid development, next-generation sequencing plays vital roles in many aspects. Here, we summarize the current knowledge on the origin and human transmission of SARS-CoV-2 based on NGS analysis. The ACE2 expression levels in various human tissues and relevant cells were compared to provide insights into the mechanism of SAS-CoV-2 infection. Gut microbiota dysbiosis observed by metagenome sequencing and the immunogenetics of COVID-19 patients according to single-cell sequencing analysis were also highlighted. Overall, the application of these sequencing techniques could be meaningful for finding novel intermediate SARS-CoV-2 hosts to block interspecies transmission. This information will further benefit SARS-CoV-2 diagnostic development and new therapeutic target discovery. The extensive application of NGS will provide powerful support for our fight against future public health emergencies.

SUBMITTER: Chen X

PROVIDER: S-EPMC7991797 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Next-Generation Sequencing Reveals the Progression of COVID-19.

Chen Xiaomin X Kang Yutong Y Luo Jing J Pang Kun K Xu Xin X Wu Jinyu J Li Xiaokun X Jin Shengwei S

Frontiers in cellular and infection microbiology 20210311

The novel coronavirus SARS-CoV-2 (causing the disease COVID-19) has caused a highly transmissible and ongoing pandemic worldwide. Due to its rapid development, next-generation sequencing plays vital roles in many aspects. Here, we summarize the current knowledge on the origin and human transmission of SARS-CoV-2 based on NGS analysis. The ACE2 expression levels in various human tissues and relevant cells were compared to provide insights into the mechanism of SAS-CoV-2 infection. Gut microbiota ...[more]

PMID: 33777844

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Dataset Information

Next-Generation Sequencing Reveals the Progression of COVID-19.

Publications

Next-Generation Sequencing Reveals the Progression of COVID-19.

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