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How should we use convalescent plasma therapies for the management of COVID-19?

ABSTRACT: Convalescent plasma (CP) from blood donors with antibodies to severe acute respiratory syndrome coronavirus 2 may benefit patients with COVID-19 by providing immediate passive immunity via transfusion or by being used to manufacture hyperimmune immunoglobulin preparations. Optimal product characteristics (including neutralizing antibody titers), transfusion volume, and administration timing remain to be determined. Preliminary COVID-19 CP safety data are encouraging, but establishing the clinical efficacy of CP requires an ongoing international collaborative effort. Preliminary results from large, high-quality randomized trials have recently started to be reported.

SUBMITTER: Wood EM

PROVIDER: S-EPMC7992504 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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How should we use convalescent plasma therapies for the management of COVID-19?

Wood Erica M EM Estcourt Lise J LJ McQuilten Zoe K ZK

Blood 20210301 12

Convalescent plasma (CP) from blood donors with antibodies to severe acute respiratory syndrome coronavirus 2 may benefit patients with COVID-19 by providing immediate passive immunity via transfusion or by being used to manufacture hyperimmune immunoglobulin preparations. Optimal product characteristics (including neutralizing antibody titers), transfusion volume, and administration timing remain to be determined. Preliminary COVID-19 CP safety data are encouraging, but establishing the clinica ...[more]

PMID: 33202419

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