Ontology highlight
ABSTRACT:
SUBMITTER: Drexler K
PROVIDER: S-EPMC7994318 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Drexler Konstantin K Schmidt Katharina M KM Jordan Katrin K Federlin Marianne M Milenkovic Vladimir M VM Liebisch Gerhard G Artati Anna A Schmidl Christian C Madej Gregor G Tokarz Janina J Cecil Alexander A Jagla Wolfgang W Haerteis Silke S Aung Thiha T Wagner Christine C Kolodziejczyk Maria M Heinke Stefanie S Stanton Evan H EH Schwertner Barbara B Riegel Dania D Wetzel Christian H CH Buchalla Wolfgang W Proescholdt Martin M Klein Christoph A CA Berneburg Mark M Schlitt Hans J HJ Brabletz Thomas T Ziegler Christine C Parkinson Eric K EK Gaumann Andreas A Geissler Edward K EK Adamski Jerzy J Haferkamp Sebastian S Mycielska Maria E ME
Life science alliance 20210323 6
Citrate is important for lipid synthesis and epigenetic regulation in addition to ATP production. We have previously reported that cancer cells import extracellular citrate via the pmCiC transporter to support their metabolism. Here, we show for the first time that citrate is supplied to cancer by cancer-associated stroma (CAS) and also that citrate synthesis and release is one of the latter's major metabolic tasks. Citrate release from CAS is controlled by cancer cells through cross-cellular co ...[more]