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Stochastic modelling of the effects of human-mobility restriction and viral infection characteristics on the spread of COVID-19.

ABSTRACT: After several months of "lockdown" as the sole answer to the COVID-19 pandemic, balancing the re-opening of society against the implementation of non-pharmaceutical measures needed for minimizing interpersonal contacts has become important. Here, we present a stochastic model that examines this problem. In our model, people are allowed to move between discrete positions on a one-dimensional grid with viral infection possible when two people are collocated at the same site. Our model features three sets of adjustable parameters, which characterize (i) viral transmission, (ii) viral detection, and (iii) degree of personal mobility, and as such, it is able to provide a qualitative assessment of the potential for second-wave infection outbreaks based on the timing, extent, and pattern of the lockdown relaxation strategies. Our results suggest that a full lockdown will yield the lowest number of infections (as anticipated) but we also found that when personal mobility exceeded a critical level, infections increased, quickly reaching a plateau that depended solely on the population density. Confinement was not effective if not accompanied by a detection/quarantine capacity surpassing 40% of the symptomatic patients. Finally, taking action to ensure a viral transmission probability of less than 0.4, which, in real life, may mean actions such as social distancing or mask-wearing, could be as effective as a soft lockdown.

SUBMITTER: Ando S

PROVIDER: S-EPMC7994631 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Coronavirus (COVID-19) has continued to be a global threat to public health. As the matter of fact, it needs unreserved effort to monitor the prevalence of the virus. However, applying an effective prediction of the prevalence is thought to be the fundamental requirement to effectively control the spreading rate. Time series models have extensively been considered as the convenient methods to predict the prevalence or spreading rate of the disease. This study, therefore, aimed to apply the Autoregressive Integrated Moving Average (ARIMA) modeling approach for projecting coronavirus (COVID-19) prevalence patterns in East Africa Countries, mainly Ethiopia, Djibouti, Sudan and Somalia. The data for the study were obtained from the reports of confirmed COVID-19 cases by the official website of Johns Hopkins University from 13th March, 2020 to 30th June, 2020.The results of the study, then, showed that in the coming four month, the number of COVID-19 positive people in Ethiopia may reach up to 56,610 from 5,846 on June 30, 2020 in average-rate scenario. However, in worst case scenario forecast, the model showed that the cases will be around 84,497. The analysis further depicted that with average interventions and control scenario, cumulative number of infected persons in Djibouti, Somalia and Sudan will increase from 4,656, 2,904 and 9,258 respectively at the end of June to 8,336, 3,961 and 21,388, which is by the end of October, 2020, after four-months. But, with insufficient intervention, the number of infected persons may grow quickly and reach up to 14,072, 10,037 and 38,174 in Djibouti, Somalia and Sudan respectively. Generally, the extent of the coronavirus spreading was increased from time to time in the past four month, until 30 th June, 2020, and it is expected to continue quicker than before for the coming 4-month, until the end of October, 2020, in Ethiopia, Djibouti, Somalia, and Sudan and more rapidly than before in Sudan and Ethiopia, while the peak will remain unknown yet. Therefore, an effective implementation of the preventive measures and a rigorous compliance by avoiding negligence with the rules such as prohibiting public gatherings, travel restrictions, personal protection measures, and social distancing may alleviate the spreading rates of the virus, particularly, Sudan and Ethiopia. Moreover, more efforts should be exerted on Ethiopian side to control the population movement across all the border areas and to strengthen border quarantining. Further, through updating more new data with continuous reconsideration of predictive model, provide useful and more precise prediction. Applying, ARIMAX-Transfer Function model in region-wise by take in to consideration of climatic data like temperature and humidity in each countries looking spatial pattern for reliable measure of COVID-19 prevalence.

Project description:BackgroundRestricting human mobility is an effective strategy used to control disease spread. However, whether mobility restriction is a proportional response to control the ongoing COVID-19 pandemic is unclear. We aimed to develop a model that can quantify the potential effects of various intracity mobility restrictions on the spread of COVID-19.MethodsIn this modelling study, we used anonymous and aggregated mobile phone sightings data to build a susceptible-exposed-infectious-recovered transmission model for COVID-19 based on the city of Shenzhen, China. We simulated how disease spread changed when we varied the type and magnitude of mobility restrictions in different transmission scenarios, with variables such as the basic reproductive number (R 0), length of infectious period, and the number of initial cases.Findings331 COVID-19 cases distributed across the ten regions of Shenzhen were reported on Feb 7, 2020. In our basic scenario (R 0 of 2·68), mobility reduction of 20-60% within the city had a notable effect on controlling COVID-19 spread: a flattening of the peak number of cases by 33% (95% UI 21-42) and delay to the peak number by 2 weeks with a 20% restriction, 66% (48-75) reduction and 4 week delay with a 40% restriction, and 91% (79-95) reduction and 14 week delay with a 60% restriction. The effects of mobility restriction were increased when combined with reductions of 25% or 50% in transmissibility of the virus. In specific analyses of mobility restrictions for individuals with symptomatic infections and for high-risk regions, these measures also had substantial effects on reducing the spread of COVID-19. For example, the peak of the epidemic was delayed by 2 weeks if the proportion of individuals with symptomatic infections who could move freely was maintained at 20%, and by 4 weeks if two high-risk regions were locked down. The simulation results were also affected by various transmission parameters.InterpretationOur model shows the effects of various types and magnitudes of mobility restrictions on controlling COVID-19 outbreaks at the city level in Shenzhen, China. The model could help policy makers to establish the optimal combinations of mobility restrictions during the COVID-19 pandemic, especially to assess the potential positive effects of mobility restriction on public health in view of the potential negative economic and societal effects.FundingGuangdong Medical Science Fund, and National Natural Science Foundation of China.

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Stochastic modelling of the effects of human-mobility restriction and viral infection characteristics on the spread of COVID-19.

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