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Genetic Polymorphisms of 5-HT Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia.


ABSTRACT: Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (HTR) genes HTR1A, HTR2A, HTR3A, and HTR2C and the gene encoding for the serotonin transporter SLC6A4 with MetS in patients with schizophrenia. A set of nine single-nucleotide polymorphisms of genes of the serotonergic system was investigated in a population of 475 patients from several Siberian regions (Russia) with a clinical diagnosis of schizophrenia. Genotyping was performed and the results were analyzed using chi-square tests. Polymorphic variant rs521018 (HTR2C) was associated with higher body mass index in patients receiving long-term antipsychotic therapy, but not with drug-induced metabolic syndrome. Rs1150226 (HTR3A) was also associated but did not meet Hardy-Weinberg equilibrium. Our results indicate that allelic variants of HTR2C genes may have consequences on metabolic parameters. MetS may have too complex a mechanistic background to be studied without dissecting the syndrome into its individual (causal) components.

SUBMITTER: Paderina DZ 

PROVIDER: S-EPMC7999828 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Genetic Polymorphisms of <i>5-HT</i> Receptors and Antipsychotic-Induced Metabolic Dysfunction in Patients with Schizophrenia.

Paderina Diana Z DZ   Boiko Anastasiia S AS   Pozhidaev Ivan V IV   Bocharova Anna V AV   Mednova Irina A IA   Fedorenko Olga Yu OY   Kornetova Elena G EG   Loonen Anton J M AJM   Semke Arkadiy V AV   Bokhan Nikolay A NA   Ivanova Svetlana A SA  

Journal of personalized medicine 20210305 3


<h4>Background</h4>Antipsychotic-induced metabolic syndrome (MetS) is a multifactorial disease with a genetic predisposition. Serotonin and its receptors are involved in antipsychotic-drug-induced metabolic disorders. The present study investigated the association of nine polymorphisms in the four 5-hydroxytryptamine receptor (<i>HTR</i>) genes <i>HTR1A</i>, <i>HTR2A</i>, <i>HTR3A</i>, and <i>HTR2C</i> and the gene encoding for the serotonin transporter <i>SLC6A4</i> with MetS in patients with s  ...[more]

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