Ontology highlight
ABSTRACT:
SUBMITTER: Shaltiel IA
PROVIDER: S-EPMC7999910 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Shaltiel Indra A IA Llopis Alba A Aprelia Melinda M Klompmaker Rob R Menegakis Apostolos A Krenning Lenno L Medema René H RH
Cells 20210304 3
Most Cyclin-dependent kinases (Cdks) are redundant for normal cell division. Here we tested whether these redundancies are maintained during cell cycle recovery after a DNA damage-induced arrest in G1. Using non-transformed RPE-1 cells, we find that while Cdk4 and Cdk6 act redundantly during normal S-phase entry, they both become essential for S-phase entry after DNA damage in G1. We show that this is due to a greater overall dependency for Cdk4/6 activity, rather than to independent functions o ...[more]