Ontology highlight
ABSTRACT:
SUBMITTER: Yu Z
PROVIDER: S-EPMC2494567 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Yu Zhengquan Z Bhandari Ambica A Mannik Jaana J Pham Thu T Xu Xiaoman X Andersen Bogi B
Developmental biology 20080415 1
Grainyhead transcription factors play an evolutionarily conserved role in regulating epidermal terminal differentiation. One such factor, the mammalian Grainyhead-like epithelial transactivator (Get1/Grhl3), is important for epidermal barrier formation. In addition to a role in barrier formation, Grainyhead genes play roles in closure of several structures such as the mouse neural tube and Drosophila wounds. Consistent with these observations, we found that Get1 knockout mice have an eye-open at ...[more]