Unknown

Dataset Information

0

Mass spectrometry reveals potential of β-lactams as SARS-CoV-2 Mpro inhibitors.


ABSTRACT: The main viral protease (Mpro) of SARS-CoV-2 is a nucleophilic cysteine hydrolase and a current target for anti-viral chemotherapy. We describe a high-throughput solid phase extraction coupled to mass spectrometry Mpro assay. The results reveal some β-lactams, including penicillin esters, are active site reacting Mpro inhibitors, thus highlighting the potential of acylating agents for Mpro inhibition.

SUBMITTER: Malla TR 

PROVIDER: S-EPMC8006714 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7651494 | biostudies-literature
| S-EPMC8018918 | biostudies-literature
| S-EPMC9235046 | biostudies-literature
| S-EPMC8166895 | biostudies-literature
| S-EPMC8315252 | biostudies-literature
| S-EPMC8292989 | biostudies-literature
| S-EPMC10171901 | biostudies-literature
| S-EPMC8099175 | biostudies-literature
| S-EPMC8073203 | biostudies-literature
| S-EPMC8398673 | biostudies-literature