Unknown

Dataset Information

0

SARS-CoV-2 viral dynamics in non-human primates.


ABSTRACT: Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (>104 virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.

SUBMITTER: Goncalves A 

PROVIDER: S-EPMC8007039 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10441782 | biostudies-literature
| S-EPMC7817048 | biostudies-literature
2023-10-18 | GSE232117 | GEO
| S-EPMC2816697 | biostudies-literature
| S-EPMC8648672 | biostudies-literature
| S-EPMC10299950 | biostudies-literature
| S-EPMC10469582 | biostudies-literature
| S-EPMC7675471 | biostudies-literature
| S-EPMC8971430 | biostudies-literature
| S-EPMC7534368 | biostudies-literature