The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
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ABSTRACT:
SUBMITTER: Shang M
PROVIDER: S-EPMC8007798 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
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The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation.
Shang Man M Yang Huijie H Yang Ran R Chen Tao T Fu Yuan Y Li Yeyi Y Fang Xianlong X Zhang Kangjian K Zhang Jianju J Li Hui H Cao Xueping X Gu Jinfa J Xiao Jianwen J Zhang Qi Q Liu Xinyuan X Yu Qiujing Q Wang Ting T
Nature communications 20210329 1
Metabolic enzymes and metabolites display non-metabolic functions in immune cell signalling that modulate immune attack ability. However, whether and how a tumour's metabolic remodelling contributes to its immune resistance remain to be clarified. Here we perform a functional screen of metabolic genes that rescue tumour cells from effector T cell cytotoxicity, and identify the embryo- and tumour-specific folate cycle enzyme methylenetetrahydrofolate dehydrogenase 2 (MTHFD2). Mechanistically, MTH ...[more]
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