Dataset Information

Total metabolic lesion volume of lymph nodes measured by ¹⁸F-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease.

ABSTRACT:

Background

To investigate the potential utility of quantitative parameters obtained by ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) in the assessment of disease severity and the occurrence of macrophage activation syndrome (MAS) in adult-onset Still's disease (AOSD).

Methods

Fifty-seven patients with AOSD who underwent pre-treatment ¹⁸F-FDG PET/CT were recruited in this study and compared with 60 age- and sex-matched healthy controls. Clinical features and laboratory data were recorded. The systemic score was assessed to determine the disease severity. The maximal standardized uptake value (SUV_max), metabolic lesion volume (MLV), and total lesion glycolysis (TLG) were used to evaluate the involved organs and tissues that abnormally accumulated ¹⁸F-FDG. Multivariate analysis was performed to identify the PET/CT-derived risk factors contributing to the AOSD-related MAS, and their diagnostic efficiency was evaluated.

Results

High ¹⁸F-FDG accumulation was observed in the bone marrow (SUV_max median, 5.10), spleen (SUV_max median, 3.70), and lymph nodes (LNs, SUV_max median, 5.55). The SUV_max of the bone marrow (rho = 0.376, p = 0.004), SUV_max of the spleen (rho = 0.450, p < 0.001), TLG_total of LNs (rho = 0.386, p = 0.017), and MLV_total of LNs (rho = 0.391, p = 0.015) were correlated with the systemic score. The SUV_max of the spleen (p = 0.017), TLG_total of LNs (p = 0.045), and MLV_total of LNs (p = 0.012) were higher in patients with MAS than in those without MAS. A MLV_total of LNs > 62.2 (OR 27.375, p = 0.042) was an independent predictive factor for MAS with a sensitivity of 80.0% and a specificity of 93.9%.

Conclusions

The glucose metabolic level of the spleen could be an effective and easy-to-use imaging indicator of disease severity, and MLV_total of LNs > 62.2 was a strong predictor of MAS occurrence in patients with AOSD.

SUBMITTER: Wan L

PROVIDER: S-EPMC8008587 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Dataset Information

Total metabolic lesion volume of lymph nodes measured by ¹⁸F-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease.

Background

Methods

Results

Conclusions

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Total metabolic lesion volume of lymph nodes measured by 18F-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease.

Background

Methods

Results

Conclusions

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Total metabolic lesion volume of lymph nodes measured by ¹⁸F-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease.