Dataset Information

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by ¹⁸F-FDG-PET is associated with the KRAS mutation status and prognosis.

ABSTRACT:

Background

Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. This study aimed to identify clinical prognostic indicators by investigating the molecular profiles of ICC and evaluating the preoperative imaging data of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET).

Methods

A retrospective analysis was performed on 50 consecutive patients with ICC who underwent curative hepatectomy after ¹⁸F-FDG-PET examination. To evaluate the molecular profiles of ICC, KRAS mutation status was assessed in resected specimens. For the assessment of glucose uptake, we observed the expression of glucose transporter-1 (GLUT-1) by immunohistochemistry. The data of ¹⁸F-FDG-PET were re-evaluated as follows: maximum standardized uptake value, metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Cut-off values were determined using receiver operating characteristic (ROC) curve analysis. Cumulative overall survival (OS) was analyzed using the Kaplan-Meier analysis.

Results

Overall, 16 (32.0%) patients had mutations in KRAS. Patients with mutated KRAS exhibited shorter OS than those with wild-type KRAS (5-year OS, 0% vs. 35.1%, P?18F-FDG-PET parameters, the MTV and TLG were significantly higher in the mutated KRAS group than in the wild-type KRAS group (P?=?0.013 and P?=?0.026, respectively). ROC curve analysis revealed a cut-off value of 38 for the MTV, with the highest accuracy (area under the curve?=?0.789; 95% confidence interval, 0.581-0.902) for predicting KRAS mutation. This cut-off value permitted stratification of OS (high vs. low: 5-year OS, 13.1% vs. 36.7%, P?=?0.008).

Conclusions

High MTV is associated with KRAS mutation and poor postoperative outcomes in patients with ICC, suggesting that the MTV of ICC measured by ¹⁸F-FDG-PET may provide useful information for tumor molecular profiles and prognosis.

SUBMITTER: Ikeno Y

PROVIDER: S-EPMC5896043 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Publications

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by <sup>18</sup>F-FDG-PET is associated with the KRAS mutation status and prognosis.

Ikeno Yoshinobu Y Seo Satoru S Iwaisako Keiko K Yoh Tomoaki T Nakamoto Yuji Y Fuji Hiroaki H Taura Kojiro K Okajima Hideaki H Kaido Toshimi T Sakaguchi Shimon S Uemoto Shinji S

Journal of translational medicine 20180411 1

<h4>Background</h4>Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. This study aimed to identify clinical prognostic indicators by investigating the molecular profiles of ICC and evaluating the preoperative ima ...[more]

PMID: 29642912

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Project description:Knowledge of the within-subject variability of 18F-FDG PET/MRI measurements is necessary for proper interpretation of quantitative PET or MRI metrics in the context of therapeutic efficacy assessments with integrated PET/MRI scanners. The goal of this study was to determine the test-retest repeatability of these metrics on PET/MRI, with comparison to similar metrics acquired by PET/CT. Methods: This prospective study enrolled subjects with pathology-proven pelvic malignancies. Baseline imaging consisted of PET/CT immediately followed by PET/MRI, using a single 370-MBq 18F-FDG dose. Repeat imaging was performed within 7 d using an identical imaging protocol, with no oncologic therapy between sessions. PET imaging on both scanners consisted of a list-mode acquisition at a single pelvic station. The MRI consisted of 2-point Dixon imaging for attenuation correction, standard sequences for anatomic correlation, and diffusion-weighted imaging. PET data were statically reconstructed using various frame durations and minimizing uptake time differences between sessions. SUV metrics were extracted for both PET/CT and PET/MRI in each imaging session. Apparent diffusion coefficient (ADC) metrics were extracted for both PET/MRI sessions. Results: The study cohort consisted of 14 subjects (13 female, 1 male) with various pelvic cancers (11 cervical, 2 rectal, 1 endometrial). For SUVmax, the within-subject coefficient of variation (wCV) appeared higher for PET/CT (8.5%-12.8%) than PET/MRI (6.6%-8.7%) across all PET reconstructions, though with no significant repeatability differences (all P values ≥ 0.08) between modalities. For lean body mass-adjusted SUVpeak, the wCVs appeared similar for PET/CT (9.9%-11.5%) and PET/MRI (9.2%-11.3%) across all PET reconstructions, again with no significant repeatability differences (all P values ≥ 0.14) between modalities. For PET/MRI, the wCV for ADCmedian of 3.5% appeared lower than the wCVs for SUVmax (6.6%-8.7%) and SULpeak (9.2%-11.3%), though without significant repeatability differences (all P values ≥ 0.23). Conclusion: For solid tumors of the pelvis, the repeatability of the evaluated SUV and ADC metrics on 18F-FDG PET/MRI is both acceptably high and similar to previously published values for 18F-FDG PET/CT and MRI, supporting the use of 18F-FDG PET/MRI for quantitative oncologic treatment response assessments.

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Dataset Information

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by ¹⁸F-FDG-PET is associated with the KRAS mutation status and prognosis.

Background

Methods

Results

Conclusions

Publications

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by <sup>18</sup>F-FDG-PET is associated with the KRAS mutation status and prognosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by 18F-FDG-PET is associated with the KRAS mutation status and prognosis.

Background

Methods

Results

Conclusions

Publications

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by <sup>18</sup>F-FDG-PET is associated with the KRAS mutation status and prognosis.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by ¹⁸F-FDG-PET is associated with the KRAS mutation status and prognosis.