Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019.
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ABSTRACT: Introduction
Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.Methods
MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.Results
Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).Conclusions
The proportion of mono-SM-resistant TB among new patients was higher.
SUBMITTER: Chun ZM
PROVIDER: S-EPMC8008859 | biostudies-literature |
REPOSITORIES: biostudies-literature
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