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Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019.

ABSTRACT:

Introduction

Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.

Methods

MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.

Results

Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were katG (S315T), rpoB (S450L), rpsL (K43R), and embB (M306V).

Conclusions

The proportion of mono-SM-resistant TB among new patients was higher.

SUBMITTER: Chun ZM 

PROVIDER: S-EPMC8008859 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Drug-Resistant Mycobacterium tuberculosis Isolates from New and Previously Treated TB Patients in China, 2017-2019.

Chun Zeng Mei ZM   Jun Jia Qing JQ  

Revista da Sociedade Brasileira de Medicina Tropical 20210322

<h4>Introduction</h4>Mycobacterium tuberculosis (MTB) is a causative agent of tuberculosis (TB) that causes death worldwide.<h4>Methods</h4>MTB was subjected to phenotypic drug-susceptibility tests (DST), and drug-resistant genes were sequenced.<h4>Results</h4>Previously treated patients were more likely to have positive smear results and exhibit drug resistance. New patients were more likely to be mono SM-resistant and less likely to be INH- and RIF-resistant. The most common mutations were kat  ...[more]