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Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs.


ABSTRACT: Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish's lateral line. We find that two interacting symmetry-breaking events - one mediated by biochemical signaling and the other by cellular mechanics - give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.

SUBMITTER: Erzberger A 

PROVIDER: S-EPMC8009062 | biostudies-literature |

REPOSITORIES: biostudies-literature

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