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Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs.

ABSTRACT: Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and in vivo imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish's lateral line. We find that two interacting symmetry-breaking events - one mediated by biochemical signaling and the other by cellular mechanics - give rise to precise rotations of cell pairs, which produce a mirror-symmetric polarity pattern in the receptor organ.

SUBMITTER: Erzberger A

PROVIDER: S-EPMC8009062 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Mechanochemical symmetry breaking during morphogenesis of lateral-line sensory organs.

Erzberger A A Jacobo A A Dasgupta A A Hudspeth A J AJ

Nature physics 20200511 9

Actively regulated symmetry breaking, which is ubiquitous in biological cells, underlies phenomena such as directed cellular movement and morphological polarization. Here we investigate how an organ-level polarity pattern emerges through symmetry breaking at the cellular level during the formation of a mechanosensory organ. Combining theory, genetic perturbations, and <i>in vivo</i> imaging, we study the development and regeneration of the fluid-motion sensors in the zebrafish's lateral line. We ...[more]

PMID: 33790985

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