Ontology highlight
ABSTRACT:
SUBMITTER: Castro J
PROVIDER: S-EPMC8009906 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Castro João J Beviano Vanessa V Paço Ana A Leitão-Castro Joana J Cadete Francisco F Francisco Miguel M Freitas Renata R
Scientific reports 20210330 1
The overexpression of hoxd13a during zebrafish fin development causes distal endochondral expansion and simultaneous reduction of the finfold, mimicking the major events thought to have happened during the fin-to-limb transition in Vertebrates. We investigated the effect of hoxd13a overexpression on putative downstream targets and found it to cause downregulation of proximal fin identity markers (meis1 and emx2) and upregulation of genes involved in skeletogenesis/patterning (fbn1, dacha) and AE ...[more]