Unknown

Dataset Information

0

LETM1: A Single Entity With Diverse Impact on Mitochondrial Metabolism and Cellular Signaling.


ABSTRACT: Nearly 2 decades since its discovery as one of the genes responsible for the Wolf-Hirschhorn Syndrome (WHS), the primary function of the leucine-zipper EF-hand containing transmembrane 1 (LETM1) protein in the inner mitochondrial membrane (IMM) or the mechanism by which it regulates mitochondrial Ca2+ handling is unresolved. Meanwhile, LETM1 has been associated with the regulation of fundamental cellular processes, such as development, cellular respiration and metabolism, and apoptosis. This mini-review summarizes the diversity of cellular functions impacted by LETM1 and highlights the multiple roles of LETM1 in health and disease.

SUBMITTER: Natarajan GK 

PROVIDER: S-EPMC8012663 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6127893 | biostudies-literature
| S-SCDT-EMM-2017-08550 | biostudies-other
| S-EPMC4200331 | biostudies-literature
| S-EPMC10825238 | biostudies-literature
| S-EPMC6095617 | biostudies-literature
| S-EPMC3874562 | biostudies-literature
| S-EPMC5698270 | biostudies-literature
| S-EPMC3683736 | biostudies-literature
| S-EPMC3920668 | biostudies-other
| S-EPMC5680261 | biostudies-literature