Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC8014923 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Gao Yuan Y Glennon Brian B He Yunliang Y Donnellan Philip P
ACS omega 20210319 12
In this work, a diffusion-theory-based model has been devised to simulate dissolution kinetics of a poorly water-soluble drug, ibuprofen. The model was developed from the Noyes-Whitney equation in which the dissolution rate term is a function of the remaining particulate surface area and the concentration gradient across the boundary layer. Other dissolution parameters include initial particle size, diffusion coefficient, material density, and diffusion boundary layer thickness. It is useful for ...[more]