Ontology highlight
ABSTRACT:
SUBMITTER: Iwai Y
PROVIDER: S-EPMC8019746 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Iwai Youichi Y Ozawa Katsuya K Yahagi Kazuko K Mishima Tsuneko T Akther Sonam S Vo Camilla Trang CT Lee Ashley Bomin AB Tanaka Mika M Itohara Shigeyoshi S Hirase Hajime H
Frontiers in neural circuits 20210322
Astrocytes elicit transient Ca<sup>2+</sup> elevations induced by G protein-coupled receptors (GPCRs), yet their role <i>in vivo</i> remains unknown. To address this, transgenic mice with astrocytic expression of the optogenetic Gq-type GPCR, Optoα1AR, were established, in which transient Ca<sup>2+</sup> elevations similar to those in wild type mice were induced by brief blue light illumination. Activation of cortical astrocytes resulted in an adenosine A1 receptor-dependent inhibition of neuron ...[more]