Project description:To examine gene expression changes duging aging in polyploid and diploid hepatocytes, diploid and polyploid hepatocytes were sorted from young and aged multi-reporter mice and their gene expressions were analyzed by high-throughput RNA sequence.
Project description:Mice was administrated with doxorubicin (DOX) to induce premature aging. Also these mice were administered intragastrically with vehicle or K35 or K27 compounds. After 20 days, these mice were sacrificed for liver tissue which were subjected to RNA sequencing to find the differentially expressed genes between control and treated groups.