The VCBS superfamily forms a third supercluster of β-propellers that includes tachylectin and integrins.

ABSTRACT:

Motivation

β-Propellers are found in great variety across all kingdoms of life. They assume many cellular roles, primarily as scaffolds for macromolecular interactions and catalysis. Despite their diversity, most β-propeller families clearly originated by amplification from the same ancient peptide-the 'blade'. In cluster analyses, β-propellers of the WD40 superfamily always formed the largest group, to which some important families, such as the α-integrin, Asp-box and glycoside hydrolase β-propellers connected weakly. Motivated by the dramatic growth of sequence databases we revisited these connections, with a special focus on VCBS-like β-propellers, which have not been analysed for their evolutionary relationships so far.

Results

We found that VCBS-like form a supercluster

SUBMITTER: Pereira J 

PROVIDER: S-EPMC8023676 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature