Dataset Information
The VCBS superfamily forms a third supercluster of β-propellers that includes tachylectin and integrins.
Ontology highlight
ABSTRACT: Motivation
β-Propellers are found in great variety across all kingdoms of life. They assume many cellular roles, primarily as scaffolds for macromolecular interactions and catalysis. Despite their diversity, most β-propeller families clearly originated by amplification from the same ancient peptide-the 'blade'. In cluster analyses, β-propellers of the WD40 superfamily always formed the largest group, to which some important families, such as the α-integrin, Asp-box and glycoside hydrolase β-propellers connected weakly. Motivated by the dramatic growth of sequence databases we revisited these connections, with a special focus on VCBS-like β-propellers, which have not been analysed for their evolutionary relationships so far.Results
We found that VCBS-like form a supercluster with integrin-like β-propellers and tachylectins, clearly delimited from the superclusters formed by WD40 and Asp-Box β-propellers. Connections between the three superclusters are made mainly through PQQ-like β-propeller. Our results present a new, greatly expanded view of the β-propeller classification landscape.Supplementary information
Supplementary data are available at Bioinformatics online.
SUBMITTER: Pereira J
PROVIDER: S-EPMC8023676 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
The VCBS superfamily forms a third supercluster of β-propellers that includes tachylectin and integrins.
Bioinformatics (Oxford, England) 20210401 24
<h4>Motivation</h4>β-Propellers are found in great variety across all kingdoms of life. They assume many cellular roles, primarily as scaffolds for macromolecular interactions and catalysis. Despite their diversity, most β-propeller families clearly originated by amplification from the same ancient peptide-the 'blade'. In cluster analyses, β-propellers of the WD40 superfamily always formed the largest group, to which some important families, such as the α-integrin, Asp-box and glycoside hydrolas ...[more]