Ontology highlight
ABSTRACT:
SUBMITTER: Elamir A
PROVIDER: S-EPMC8024284 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Elamir Amal A Ajith Saniha S Sawaftah Nour Al NA Abuwatfa Waad W Mukhopadhyay Debasmita D Paul Vinod V Al-Sayah Mohammad H MH Awad Nahid N Husseini Ghaleb A GA
Scientific reports 20210406 1
The functionalization of liposomes with monoclonal antibodies is a potential strategy to increase the specificity of liposomes and reduce the side-effects associated with chemotherapeutic agents. The active targeting of the Human Epidermal growth factor Receptor 2 (HER2), which is overexpressed in HER2 positive breast cancer cells, can be achieved by coating liposomes with an anti-HER2 monoclonal antibody. In this study, we synthesized calcein and Doxorubicin-loaded immunoliposomes functionalize ...[more]