Unknown

Dataset Information

0

Ultrasound-Triggered Delivery of Iproplatin from Microbubble-Conjugated Liposomes.


ABSTRACT: The PtIV prodrug iproplatin has been actively loaded into liposomes using a calcium acetate gradient, achieving a 3-fold enhancement in drug concentration compared to passive loading strategies. A strain-promoted cycloaddition reaction (azide- dibenzocyclooctyne) was used to attach iproplatin-loaded liposomes L(Pt) to gas-filled microbubbles (M), forming an ultrasound-responsive drug delivery vehicle [M-L(Pt)]. Ultrasound-triggered release of iproplatin from the microbubble-liposome construct was evaluated in cellulo. Breast cancer (MCF-7) cells treated with both free iproplatin and iproplatin-loaded liposome-microbubbles [M-L(Pt)] demonstrated an increase in platinum concentration when exposed to ultrasound. No appreciable platinum uptake was observed in MCF-7 cells following treatment with L(Pt) only or L(Pt)+ultrasound, suggesting that microbubble-mediated ultrasonic release of platinum-based drugs from liposomal carriers enables greater control over drug delivery.

SUBMITTER: Browning R 

PROVIDER: S-EPMC8634767 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8024284 | biostudies-literature
| S-EPMC7076495 | biostudies-literature
| S-EPMC8172941 | biostudies-literature
| S-EPMC9315635 | biostudies-literature
| S-EPMC8229429 | biostudies-literature
| S-EPMC4165777 | biostudies-literature
| S-EPMC3136211 | biostudies-literature
| S-EPMC3433587 | biostudies-literature
| S-EPMC6540049 | biostudies-literature
| S-EPMC3470804 | biostudies-literature