Unknown

Dataset Information

0

Improvement in Retinal Capillary Rarefaction After Valsartan Treatment in Hypertensive Patients.


ABSTRACT: Decreased capillary density influences vascular resistance and perfusion. The authors aimed to investigate the influence of the renin-angiotensin receptor blocker valsartan on retinal capillary rarefaction in hypertensive patients. Retinal vascular parameters were measured noninvasively and in vivo by scanning laser Doppler flowmetry before and after 4 weeks of treatment with valsartan in 95 patients with hypertension stage 1 or 2 and compared with 55 healthy individuals. Retinal capillary rarefaction was determined with the parameters intercapillary distance (ICD) and capillary area (CapA). In hypertensive patients, ICD decreased (23.4±5.5 μm vs 21.5±5.6 μm, P<.001) and CapA increased (1564±621 vs 1776±795, P=.001) after valsartan treatment compared with baseline. Compared with healthy normotensive controls (ICD 20.2±4.2 μm, CapA 1821±652), untreated hypertensive patients showed greater ICD (P<.001) and smaller CapA (P=.019), whereas treated hypertensive patients showed no difference in ICD (P=.126) and CapA (P=.728). Therapy with valsartan for 4 weeks diminished capillary rarefaction in hypertensive patients.

SUBMITTER: Jumar A 

PROVIDER: S-EPMC8031650 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5147800 | biostudies-literature
| S-EPMC5740840 | biostudies-literature
| S-EPMC4446817 | biostudies-other
2023-01-01 | E-MTAB-11355 | biostudies-arrayexpress
| S-EPMC5118486 | biostudies-literature
| S-EPMC7422770 | biostudies-literature
| S-EPMC8108859 | biostudies-literature
2023-06-29 | GSE165218 | GEO
| S-EPMC5328159 | biostudies-literature
| S-EPMC5749705 | biostudies-literature