New methods for quantifying rapidity of action potential onset differentiate neuron types.

ABSTRACT: Two new methods for quantifying the rapidity of action potential onset have lower relative standard deviations and better distinguish neuron cell types than current methods. Action potentials (APs) in most central mammalian neurons exhibit sharp onset dynamics. The main views explaining such an abrupt onset differ. Some studies suggest sharp onsets reflect cooperative sodium channels activation, while others suggest they reflect AP backpropagation from the axon initial segment. However, AP onset rapidity is defined subjectively in these studies, often using the slope at an arbitrary value on the phase plot. Thus, we proposed more systematic methods using the membrane potential's second-time derivative ([Formula: see text]) peak width. Here, the AP rapidity was measured for four different c

SUBMITTER: Aldohbeyb AA 

PROVIDER: S-EPMC8032118 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature