Alpha-mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway.
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ABSTRACT:
SUBMITTER: Jiang M
PROVIDER: S-EPMC8034454 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
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Alpha-mangostin improves endothelial dysfunction in db/db mice through inhibition of aSMase/ceramide pathway.
Jiang Meng M Huang Shanya S Duan Wang W Liu Qiaoshu Q Lei Minxiang M
Journal of cellular and molecular medicine 20210314 7
Diabetic vascular complications are the leading causes of death and disability in patients with diabetes. Alpha-mangostin has been reported to have anti-diabetic capacity in recent years. Here, we investigated the protective function of alpha-mangostin on endothelium in vitro and in vivo experiments. We also observed that alpha-mangostin improved impaired endothelium-dependent vasodilation (EDV) of diabetic animals while it limited the aSMase/ceramide pathway and up-regulated eNOS/NO pathway in ...[more]
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