Retrospective SPECT/CT dosimetry following transarterial radioembolization.

ABSTRACT: Transarterial radioembolization (TARE) effectively treats unresectable primary and metastatic liver tumors through intra-arterial injection of Yttrium-90 (⁹⁰ Y) beta particle emitting microspheres which implant around the tumor. Current dosimetry models are highly simplistic and there is a large need for an image-based dosimetry post-TARE, which would improve treatment safety and efficacy. Current post-TARE imaging is ⁹⁰ Y bremsstrahlung SPECT/CT and we study the use of these images for dosimetry. Retrospective image review of ten patients having a Philips Healthcare^TM SPECT/CT following TARE SIR-Spheres® implantation. Emission series with attenuation correction were resampled to 3 mm resolution and used to create image-based dose distributions. Dose distri

SUBMITTER: Thompson BC 

PROVIDER: S-EPMC8035553 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature