Ontology highlight
ABSTRACT:
SUBMITTER: Jarman OD
PROVIDER: S-EPMC8039183 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Jarman Owen D OD Biner Olivier O Hirst Judy J
Biochimica et biophysica acta. Bioenergetics 20201213 3
F<sub>1</sub>F<sub>O</sub>-ATP synthase is a crucial metabolic enzyme that uses the proton motive force from respiration to regenerate ATP. For maximum thermodynamic efficiency ATP synthesis should be fully reversible, but the enzyme from Paracoccus denitrificans catalyzes ATP hydrolysis at far lower rates than it catalyzes ATP synthesis, an effect often attributed to its unique ζ subunit. Recently, we showed that deleting ζ increases hydrolysis only marginally, indicating that other common inhi ...[more]