Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi H
PROVIDER: S-EPMC8039291 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Yamaguchi Hiroyuki H Kitami Kohei K Wu Xiao X He Li L Wang Jianbo J Wang Bin B Komatsu Yoshihiro Y
Frontiers in physiology 20210329
Cleft palate is one of the most common craniofacial birth defects, however, little is known about how changes in the DNA damage response (DDR) cause cleft palate. To determine the role of DDR during palatogenesis, the DDR process was altered using a pharmacological intervention approach. A compromised DDR caused by a poly (ADP-ribose) polymerase (PARP) enzyme inhibitor resulted in cleft palate in wild-type mouse embryos, with increased DNA damage and apoptosis. In addition, a mouse genetic appro ...[more]