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A Pd-Catalyzed [4 + 2] Annulation Approach to Fluorinated N-Heterocycles.


ABSTRACT: 3-Fluoro- and trifluoromethylthio-piperidines represent important building blocks for discovery chemistry. We report a simple and efficient method to access analogs of these compounds that are armed with rich functionality allowing them to be chemoselectively derivatized with high diastereocontrol.

SUBMITTER: Garcia-Vazquez V 

PROVIDER: S-EPMC8041373 | biostudies-literature |

REPOSITORIES: biostudies-literature

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