Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks.
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ABSTRACT: A practical access to four new halogen-substituted pyrrole building blocks was realized in two to five synthetic steps from commercially available starting materials. The target compounds were prepared on a 50 mg to 1 g scale, and their conversion to nanomolar inhibitors of bacterial DNA gyrase B was demonstrated for three of the prepared building blocks to showcase the usefulness of such chemical motifs in medicinal chemistry.
SUBMITTER: Cotman AE
PROVIDER: S-EPMC8047689 | biostudies-literature |
REPOSITORIES: biostudies-literature
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