Ontology highlight
ABSTRACT:
SUBMITTER: Low HB
PROVIDER: S-EPMC8052345 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Low Heng Boon HB Wong Zhen Lim ZL Wu Bangyuan B Kong Li Ren LR Png Chin Wen CW Cho Yik-Lam YL Li Chun-Wei CW Xiao Fengchun F Xin Xuan X Yang Henry H Loo Jia Min JM Lee Fiona Yi Xin FYX Tan Iain Bee Huat IBH DasGupta Ramanuj R Shen Han-Ming HM Schwarz Herbert H Gascoigne Nicholas R J NRJ Goh Boon Cher BC Xu Xiaohong X Zhang Yongliang Y
Nature communications 20210416 1
Drug resistance is a major obstacle to the treatment of most human tumors. In this study, we find that dual-specificity phosphatase 16 (DUSP16) regulates resistance to chemotherapy in nasopharyngeal carcinoma, colorectal cancer, gastric and breast cancer. Cancer cells expressing higher DUSP16 are intrinsically more resistant to chemotherapy-induced cell death than cells with lower DUSP16 expression. Overexpression of DUSP16 in cancer cells leads to increased resistance to cell death upon chemoth ...[more]