Unknown

Dataset Information

0

Free Fatty Acid Receptors as Mediators and Therapeutic Targets in Liver Disease.


ABSTRACT: Free fatty acid receptors (FFARs) are a class of G protein-coupled receptors (GPCRs) that have wide-ranging effects on human physiology. The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. Short-chain (<6 carbon) fatty acids target FFAR2/GPR43 and FFAR3/GPR41. Medium- and long-chain fatty acids (6-12 and 13-21 carbon, respectively) target both FFAR1/GPR40 and FFAR4/GPR120. Signaling through FFARs has been implicated in non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), intestinal failure-associated liver disease (IFALD), and a variety of other liver disorders. FFARs are now regarded as targets for therapeutic intervention for liver disease, diabetes, obesity, hyperlipidemia, and metabolic syndrome. In this review, we provide an in-depth, focused summary of the role FFARs play in liver health and disease.

SUBMITTER: Secor JD 

PROVIDER: S-EPMC8058363 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4222138 | biostudies-literature
| S-EPMC8666813 | biostudies-literature
| S-EPMC10290856 | biostudies-literature
| S-EPMC8616422 | biostudies-literature
| S-EPMC4919666 | biostudies-literature
| S-EPMC2697779 | biostudies-literature
| S-EPMC6230844 | biostudies-literature
| S-EPMC10286797 | biostudies-literature
| S-EPMC7852578 | biostudies-literature
| S-EPMC7215455 | biostudies-literature