Schizophrenia polygenic risk scores in youth mental health: preliminary associations with diagnosis, clinical stage and functioning.

ABSTRACT:

Background

The schizophrenia polygenic risk score (SCZ-PRS) is an emerging tool in psychiatry.

Aims

We aimed to evaluate the utility of SCZ-PRS in a young, transdiagnostic, clinical cohort.

Method

SCZ-PRSs were calculated for young people who presented to early-intervention youth mental health clinics, including 158 patients of European ancestry, 113 of whom had longitudinal outcome data. We examined associations between SCZ-PRS and diagnosis, clinical stage and functioning at initial assessment, and new-onset psychotic disorder, clinical stage transition and functional course over time in contact with services.

Results

Compared with a control group, patients had elevated PRSs for schizophrenia, bipolar disorder and depression, but not for any non-psychiatric p

SUBMITTER: Crouse JJ 

PROVIDER: S-EPMC8058892 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature