Interactive Effects of HLA and GM Alleles on the Development of Alzheimer Disease.

ABSTRACT:

Objective

We investigated whether particular immunoglobulin GM (γ marker) alleles-individually or epistatically with a known human leukocyte antigen (HLA) risk allele-were associated with the development of Alzheimer disease (AD).

Methods

Using a prospective cohort study design, we genotyped DNA samples from 209 African American (AA) and 638 European American (EA) participants for IgG1 (GM 3 and GM 17), IgG2 (GM 23+ and GM 23-), and HLA-DRB1 rs9271192 (A/C) alleles by TaqMan and rhAMP genotyping assays.

Results

In EA subjects, none of the GM or HLA alleles-individually or epistatically-were associated with time to development of AD. In AA subjects, GM and HLA alleles individually were not associated with time to development of AD. However, there was a significa

SUBMITTER: Pandey JP 

PROVIDER: S-EPMC8063623 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature