Dataset Information

Complete Genome Sequence of Anaerostipes caccae Strain L1-92^T, a Butyrate-Producing Bacterium Isolated from Human Feces.

ABSTRACT: Anaerostipes caccae strain L1-92^T is a well-known butyrate-producing bacterium that has been isolated from human feces. In this announcement, we present the complete genome sequence of A. caccae strain L1-92^T, which comprises 3,590,719 bp with a G+C content of 44.30%. The genome harbors 3,369 predicted protein-coding genes.

SUBMITTER: Morinaga K

PROVIDER: S-EPMC8063638 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Complete Genome Sequence of Anaerostipes caccae Strain L1-92T, a Butyrate-Producing Bacterium Isolated from Human Feces.

Morinaga Kana K Kusada Hiroyuki H Watanabe Miho M Tamaki Hideyuki H

Microbiology resource announcements 20210422 16

Anaerostipes caccae strain L1-92T is a well-known butyrate-producing bacterium that has been isolated from human feces. In this announcement, we present the complete genome sequence of A. caccae strain L1-92T, which comprises 3,590,719 bp with a G+C content of 44.30%. The genome harbors 3,369 predicted protein-coding genes. ...[more]

PMID: 33888495

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Project description:BackgroundThe gut microbiota is a key regulator of bone metabolism. Investigating the relationship between the gut microbiota and bone remodeling has revealed new avenues for the treatment of bone-related disorders. Despite significant progress in understanding gut microbiota-bone interactions in mammals, research on avian species remains limited. Birds have unique bone anatomy and physiology to support egg-laying. However, whether and how the gut microbiota affects bone physiology in birds is still unknown. In this study, we utilized laying hens as a research model to analyze bone development patterns, elucidate the relationships between bone and the gut microbiota, and mine probiotics with osteomodulatory effects.ResultsAging led to a continuous increase in bone mineral density in the femur of laying hens. The continuous deposition of medullary bone in the bone marrow cavity of aged laying hens led to significant trabecular bone loss and weakened bone metabolism. The cecal microbial composition significantly shifted before and after sexual maturity, with some genera within the class Clostridia potentially linked to postnatal bone development in laying hens. Four bacterial strains associated with bone development, namely Blautia coccoides CML164, Fournierella sp002159185 CML151, Anaerostipes caccae CML199 (ANA), and Romboutsia lituseburensis CML137, were identified and assessed in chicks with low bacterial loads and chicken primary osteoblasts. Among these, ANA demonstrated the most significant promotion of bone formation both in vivo and in vitro, primarily attributed to butyrate in its fermentation products. A long-term feeding experiment of up to 72 weeks confirmed that ANA enhanced bone development during sexual maturity by improving the immune microenvironment of the bone marrow in laying hens. Dietary supplementation of ANA for 50 weeks prevented excessive medullary bone deposition and mitigated aging-induced trabecular bone loss.ConclusionsThese findings highlight the beneficial effects of ANA on bone physiology, offering new perspectives for microbial-based interventions for bone-related disorders in both poultry and possibly extending to human health. Video Abstract.

Dataset Information

Complete Genome Sequence of Anaerostipes caccae Strain L1-92^T, a Butyrate-Producing Bacterium Isolated from Human Feces.

Publications

Complete Genome Sequence of Anaerostipes caccae Strain L1-92<sup>T</sup>, a Butyrate-Producing Bacterium Isolated from Human Feces.

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