Ontology highlight
ABSTRACT:
SUBMITTER: Baek SH
PROVIDER: S-EPMC8064376 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Baek Seung Han SH Foer Dinah D Cahill Katherine N KN Israel Elliot E Maiorino Enrico E Röhl Annika A Boyce Joshua A JA Weiss Scott T ST
Journal of personalized medicine 20210325 4
There is an acute need for advances in pharmacologic therapies and a better understanding of novel drug targets for severe asthma. Imatinib, a tyrosine kinase inhibitor, has been shown to improve forced expiratory volume in 1 s (FEV<sub>1</sub>) in a clinical trial of patients with severe asthma. In a pilot study, we applied systems biology approaches to epithelium gene expression from these clinical trial patients treated with imatinib to better understand lung function response with imatinib t ...[more]