Unknown

Dataset Information

0

Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?


ABSTRACT: Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs' deleterious impact in the TME by either inhibiting their recruitment, blocking their expansion, favoring their plastic transformation into other CD4+ T-cell subsets, blocking their suppressive function or depleting them specifically in the TME to avoid severe deleterious effects associated with Treg neutralization/depletion in the periphery and normal tissues.

SUBMITTER: Cinier J 

PROVIDER: S-EPMC8069615 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Recruitment and Expansion of Tregs Cells in the Tumor Environment-How to Target Them?

Cinier Justine J   Hubert Margaux M   Besson Laurie L   Di Roio Anthony A   Rodriguez Céline C   Lombardi Vincent V   Caux Christophe C   Ménétrier-Caux Christine C  

Cancers 20210413 8


Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs' deleterious impact in the TME by either inhibi  ...[more]

Similar Datasets

| S-EPMC11923918 | biostudies-literature
| S-EPMC6302945 | biostudies-literature
| S-EPMC1550279 | biostudies-literature
| S-EPMC7529787 | biostudies-literature
| S-EPMC4688361 | biostudies-literature
| S-EPMC2735938 | biostudies-literature
| S-EPMC7117689 | biostudies-literature
| S-EPMC4622478 | biostudies-other
| S-EPMC7526557 | biostudies-literature
| S-EPMC9427669 | biostudies-literature