Ontology highlight
ABSTRACT:
SUBMITTER: Cinier J
PROVIDER: S-EPMC8069615 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Cinier Justine J Hubert Margaux M Besson Laurie L Di Roio Anthony A Rodriguez Céline C Lombardi Vincent V Caux Christophe C Ménétrier-Caux Christine C
Cancers 20210413 8
Regulatory T cells (Tregs) are present in a large majority of solid tumors and are mainly associated with a poor prognosis, as their major function is to inhibit the antitumor immune response contributing to immunosuppression. In this review, we will investigate the mechanisms involved in the recruitment, amplification and stability of Tregs in the tumor microenvironment (TME). We will also review the strategies currently developed to inhibit Tregs' deleterious impact in the TME by either inhibi ...[more]