Serial sodium values and adverse outcomes in heart failure with preserved ejection fraction.

ABSTRACT:

Objective

The purpose of our study is to examine whether serial measurements of serum sodium values after diagnosis identify a higher-risk subset of patients with heart failure with preserved ejection fraction.

Methods

We identified 50,932 subjects with HFpEF with 759,577 recorded sNa measurements (mean age 72 ± 11 years) using a validated algorithm in the VA national database from 2002 to 2012. We examined the association of repeated measures of sNa with mortality using a multivariable Cox proportional hazards model.

Results

After a median follow-up of 2.9 years (IQR: 1.2-5.4), 19,011 deaths occurred. After adjusting for age, sex, race, BMI, glomerular filtration rate, potassium, coronary artery disease, hypertension, hyperlipidemia, atrial fibrillation, pulmonary di

SUBMITTER: Imran TF 

PROVIDER: S-EPMC8077233 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature