Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC8078843 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Statistics in biopharmaceutical research 20201009 2
In this paper, we illustrate the method of designing a group-sequential randomized clinical trial based on the difference in restricted mean survival time (RMST). The procedure is based on theoretical formulations of Murray and Tsiatis (1999). We also present a numerical example in designing a cardiology surgical trial. Various practical considerations are discussed. R codes are provided in the Supplementary Materials. We conclude that the group-sequential design for RMST is a viable option in p ...[more]