Involvement of myocyte enhancer factor 2c in the pathogenesis of autism spectrum disorder.

ABSTRACT: Myocyte enhancer factor 2 (MEF2), a family of transcription factor of MADS (minichromosome maintenance 1, agamous, deficiens and serum response factor)-box family needed in the growth and differentiation of a variety of human cells, such as neural, immune, endothelial, and muscles. As per existing literature, MEF2 transcription factors have also been associated with synaptic plasticity, the developmental mechanisms governing memory and learning, and several neurologic conditions, like autism spectrum disorders (ASDs). Recent genomic findings have ascertained a link between MEF2 defects, particularly in the MEF2C isoform and the ASD. In this review, we summarized a concise overview of the general regulation, structure and functional roles of the MEF2C</

SUBMITTER: Chaudhary R 

PROVIDER: S-EPMC8082549 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature