Ontology highlight
ABSTRACT:
SUBMITTER: Cheng MH
PROVIDER: S-EPMC8082696 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Cheng Mary Hongying MH Porritt Rebecca A RA Rivas Magali Noval MN Krieger James M JM Ozdemir Asli Beyza AB Garcia Gustavo G Arumugaswami Vaithilingaraja V Fries Bettina C BC Arditi Moshe M Bahar Ivet I
Structure (London, England : 1993) 20210429 9
We recently discovered a superantigen-like motif sequentially and structurally similar to a staphylococcal enterotoxin B (SEB) segment, near the S1/S2 cleavage site of the SARS-CoV-2 spike protein, which might explain the multisystem inflammatory syndrome (MIS-C) observed in children and the cytokine storm in severe COVID-19 patients. We show here that an anti-SEB monoclonal antibody (mAb), 6D3, can bind this viral motif at its polybasic (PRRA) insert to inhibit infection in live virus assays. T ...[more]