Ontology highlight
ABSTRACT:
SUBMITTER: Choi WS
PROVIDER: S-EPMC8084130 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Choi Won Seok WS Kang Hyun Sik HS Kim Hong Jo HJ Lee Wang Tae WT Sohn Uy Dong UD Lee Ji-Yun JY
PloS one 20210429 4
Asthma is a well-known bronchial disease that causes bronchial inflammation, narrowing of the bronchial tubes, and bronchial mucus secretion, leading to bronchial blockade. In this study, we investigated the association between phosphodiesterase (PDE), specifically PDE1, and asthma using 3-isobutyl-1-methylxanthine (IBMX; a non-specific PDE inhibitor) and vinpocetine (Vinp; a PDE1 inhibitor). Balb/c mice were randomized to five treatment groups: control, ovalbumin (OVA), OVA + IBMX, OVA + Vinp, ...[more]