Unknown

Dataset Information

0

Comprehensive and Computable Molecular Diagnostic Panel (C2Dx) From Small Volume Specimens for Precision Oncology: Molecular Subtyping of Non-Small Cell Lung Cancer From Fine Needle Aspirates.


ABSTRACT: The Comprehensive, Computable NanoString Diagnostic gene panel (C2Dx) is a promising solution to address the need for a molecular pathological research and diagnostic tool for precision oncology utilizing small volume tumor specimens. We translate subtyping-related gene expression patterns of Non-Small Cell Lung Cancer (NSCLC) derived from public transcriptomic data which establish a highly robust and accurate subtyping system. The C2Dx demonstrates supreme performance on the NanoString platform using microgram-level FNA samples and has excellent portability to frozen tissues and RNA-Seq transcriptomic data. This workflow shows great potential for research and the clinical practice of cancer molecular diagnosis.

SUBMITTER: Su J 

PROVIDER: S-EPMC8085404 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC7794969 | biostudies-literature
| S-EPMC3378660 | biostudies-literature
| S-EPMC5760337 | biostudies-literature
| S-EPMC4721927 | biostudies-literature
| S-EPMC4425530 | biostudies-literature
2024-08-26 | GSE240953 | GEO
| S-EPMC6694023 | biostudies-literature
| S-EPMC6710823 | biostudies-literature
| S-EPMC8269161 | biostudies-literature
2024-08-26 | GSE240951 | GEO