Ontology highlight
ABSTRACT:
SUBMITTER: Jabeena CA
PROVIDER: S-EPMC8095176 | biostudies-literature | 2021 Jan-Jun
REPOSITORIES: biostudies-literature
Jabeena C A CA Govindaraju Gayathri G Rawat Mukul M Gopi Soundhararajan S Sethumadhavan Devadathan Valiyamangalath DV Jaleel Abdul A Sasankan Dhakshmi D Karmodiya Krishanpal K Rajavelu Arumugam A
The Journal of biological chemistry 20210101
Epigenetic modifications have emerged as critical regulators of virulence genes and stage-specific gene expression in Plasmodium falciparum. However, the specific roles of histone core epigenetic modifications in regulating the stage-specific gene expression are not well understood. In this study, we report an unconventional trimethylation at lysine 64 on histone 3 (H3K64me3) and characterize its functional relevance in P. falciparum. We show that PfSET4 and PfSET5 proteins of P. falciparum meth ...[more]