Unknown

Dataset Information

0

Genetic factors affect the susceptibility to bacterial infections in diabetes.


ABSTRACT: Diabetes increases the risk of bacterial infections. We investigated whether common genetic variants associate with infection susceptibility in Finnish diabetic individuals. We performed genome-wide association studies and pathway analysis for bacterial infection frequency in Finnish adult diabetic individuals (FinnDiane Study; N = 5092, Diabetes Registry Vaasa; N = 4247) using national register data on antibiotic prescription purchases. Replication analyses were performed in a Swedish diabetic population (ANDIS; N = 9602) and in a Finnish non-diabetic population (FinnGen; N = 159,166). Genome-wide data indicated moderate but significant narrow-sense heritability for infection susceptibility (h2 = 16%, P = 0.02). Variants on chromosome 2 were associated with reduced infection susceptibility (rs62192851, P = 2.23 × 10-7). Homozygotic carriers of the rs62192851 effect allele (N = 44) had a 37% lower median annual antibiotic purchase rate, compared to homozygotic carriers of the reference allele (N = 4231): 0.38 [IQR 0.22-0.90] and 0.60 [0.30-1.20] respectively, P = 0.01). Variants rs6727834 and rs10188087, in linkage disequilibrium with rs62192851, replicated in the FinnGen-cohort (P < 0.05), but no variants replicated in the ANDIS-cohort. Pathway analysis suggested the IRAK1 mediated NF-κB activation through IKK complex recruitment-pathway to be a mediator of the phenotype. Common genetic variants on chromosome 2 may associate with reduced risk of bacterial infections in Finnish individuals with diabetes.

SUBMITTER: Simonsen JR 

PROVIDER: S-EPMC8096814 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3716642 | biostudies-literature
2022-06-27 | GSE206095 | GEO
| 2718871 | ecrin-mdr-crc
| S-EPMC6369875 | biostudies-literature
| S-EPMC3779444 | biostudies-literature
| S-EPMC3475324 | biostudies-literature
| S-EPMC9378502 | biostudies-literature
| S-EPMC4332275 | biostudies-other
2013-04-16 | E-GEOD-40234 | biostudies-arrayexpress
| S-EPMC7996259 | biostudies-literature