Daptomycin Resistance in Enterococcus faecium Can Be Delayed by Disruption of the LiaFSR Stress Response Pathway.
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ABSTRACT:
SUBMITTER: Prater AG
PROVIDER: S-EPMC8097453 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Daptomycin Resistance in Enterococcus faecium Can Be Delayed by Disruption of the LiaFSR Stress Response Pathway.
Prater Amy G AG Mehta Heer H HH Beabout Kathryn K Supandy Adeline A Miller William R WR Tran Truc T TT Arias Cesar A CA Shamoo Yousif Y
Antimicrobial agents and chemotherapy 20210318 4
LiaFSR signaling plays a major role in mediating daptomycin (DAP) resistance in enterococci, and the lack of a functional LiaFSR pathway leads to DAP hypersusceptibility. Using <i>in vitro</i> experimental evolution, we evaluated how <i>Enterococcus faecium</i> with a <i>liaR</i> response regulator gene deletion evolved DAP resistance. We found that knocking out LiaFSR signaling significantly delayed the onset of resistance, but resistance could emerge eventually through various alternate mechan ...[more]
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