Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC8098682 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhang Yanling Y Qin Wei W Liu Dongyang D Liu Yuan Y Wang Chu C
Chemical science 20210331 17
Itaconate is an immunoregulatory and anti-bacterial metabolite, and plays important roles in host-pathogen interactions. Chemoproteomic strategies have been used to explore the anti-inflammatory effects of itaconate on activated macrophages and it has been found that many key proteins in immune pathways were modified; however, how itaconate modulates pathogens was not fully understood. Here, we have designed and synthesized a series of itaconate-based bioorthogonal probes, which enable quantitat ...[more]