Association between baseline LDL-C and prognosis among patients with coronary artery disease and advanced kidney disease.

ABSTRACT:

Background

Lower low-density lipoprotein cholesterol (LDL-C) is significantly associated with improved prognosis in patients with coronary artery disease (CAD). However, LDL-C reduction does not decrease all-cause mortality among CAD patients when renal function impairs. The association between low baseline LDL-C (< 1.8 mmol/L) and mortality is unknown among patients with CAD and advanced kidney disease (AKD). The current study aimed to evaluate prognostic value of low baseline LDL-C level for all-cause death in these patients.

Methods

In this observational study, 803 CAD patients complicated with AKD (eGFR < 30 mL/min/1.73 m²) were enrolled between January 2008 to December 2018. Patients were divided into two groups (LDL-C < 1.8 mmol/L, n = 138; LDL-C ≥ 1.8 mmol/

SUBMITTER: Wang B 

PROVIDER: S-EPMC8101096 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature