Ontology highlight
ABSTRACT:
SUBMITTER: Moruzzi N
PROVIDER: S-EPMC8107091 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Moruzzi Noah N Lazzeri-Barcelo Francesca F Valladolid-Acebes Ismael I Moede Tilo T Paschen Meike M Leibiger Barbara B Berggren Per-Olof PO Leibiger Ingo B IB
Journal of cellular and molecular medicine 20210319 10
The two insulin receptor (IR) isoforms IR-A and IR-B are responsible for the pleiotropic actions of insulin and insulin-like growth factors. Consequently, changes in IR isoform expression and in the bioavailability of their ligands will impact on IR-mediated functions. Although alteration of IR isoform expression has been linked to insulin resistance, knowledge of IR isoform expression and mechanisms underlying tissue/cell-type-specific changes in metabolic disease are lacking. Using mouse model ...[more]