Adipose tissue natriuretic peptide receptor expression is related to insulin sensitivity in obesity and diabetes.

ABSTRACT: Cardiac natriuretic peptides (NPs) bind to two receptors (NPRA-mediator of signaling; NPRC-clearance receptor) whose ratio, NPRR (NPRA/NPRC), determines the NP bioactivity. This study investigated the relationship of NP receptor gene expression in adipose tissue and muscle with obesity and glucose intolerance. Prospectively, the study also assessed whether changes in NP receptor expression and thermogenic gene markers accompanied improvements of insulin sensitivity.A cross-sectional study of subjects with a wide range of BMI and glucose tolerance (n?=?50) was conducted, as well as a randomized 12-week trial of subjects with type 2 diabetes mellitus (T2DM) treated with pioglitazone (n?=?9) or placebo (n?=?10).NPRR mRNA was significantly lower in adipose tissue of subjects with obesity when compared with lean subjects (P???0.001). NPRR decreased with progression from normal glucose tolerance to T2DM (P?

SUBMITTER: Kovacova Z 

PROVIDER: S-EPMC5067565 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature